Beilstein J. Org. Chem.2023,19, 956–981, doi:10.3762/bjoc.19.72
Anup Biswas Department of Chemistry, Hooghly Women’s College, Vivekananda Road, Pipulpati, Hooghly - 712103, WB, India 10.3762/bjoc.19.72 Abstract The aza-Friedel–Craftsreaction allows an efficient coupling of electron-rich aromatic systems with imines for the facile incorporation of aminoalkyl
stereoselectivity is also explained.
Keywords: asymmetric; aza-Friedel–Craftsreaction; H-bonding; organocatalysis; stereoselectivity; Introduction
The ease of a chemical transformation depends on the thermodynamic instability of a chemical bond owing to its fast cleavage under mild reaction conditions. A C–H
with the elimination of a H+ ion to form the functionalized aromatic moieties. The aza-Friedel–Craftsreaction is a subclass of the originally reported transformation that couples an imine with an aromatic system allowing for a facile incorporation of an alkylamine functionality into the aromatic
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Graphical Abstract
Scheme 1:
First organocatalyzed asymmetric aza-Friedel–Crafts reaction.